Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710
Phone: 
919.684.0058

Overview

Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Zhao, Peishen, et al. “Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.J Biol Chem, vol. 289, no. 39, Sept. 2014, pp. 27215–34. Pubmed, doi:10.1074/jbc.M114.599712. Full Text

Lindy, Amanda S., et al. “TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.Nat Commun, vol. 5, Sept. 2014, p. 4734. Pubmed, doi:10.1038/ncomms5734. Full Text Open Access Copy

Liedtke, Wolfgang, et al. “Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?J Invest Dermatol, vol. 134, no. 9, Sept. 2014, pp. 2310–12. Pubmed, doi:10.1038/jid.2014.250. Full Text

Leddy, Holly A., et al. “Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.Faseb J, vol. 28, no. 6, June 2014, pp. 2525–37. Pubmed, doi:10.1096/fj.13-245936. Full Text

O’Conor, Christopher J., et al. “TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.Proc Natl Acad Sci U S A, vol. 111, no. 4, Jan. 2014, pp. 1316–21. Pubmed, doi:10.1073/pnas.1319569111. Full Text

O’Conor, C. J., et al. “Osmotic or chemical activation of the TRPV4 ion channel enhances the development of chondrocyte-based tissue engineered cartilage.” Asme 2013 Summer Bioengineering Conference, Sbc 2013, vol. 1 B, Dec. 2013. Scopus, doi:10.1115/SBC2013-14042. Full Text

Yeo, Michele, et al. “Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity.Epigenetics, vol. 8, no. 11, Nov. 2013, pp. 1128–32. Pubmed, doi:10.4161/epi.26406. Full Text

Moore, C., et al. “Erratum: UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling (Proceedings of the National Academy of Sciences of the United States of America).” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 38, Oct. 2013, p. 15502. Scopus, doi:10.1073/pnas.1315603110. Full Text

Xia, Yang, et al. “TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.Am J Physiol Cell Physiol, vol. 305, no. 7, Oct. 2013, pp. C704–15. Pubmed, doi:10.1152/ajpcell.00099.2013. Full Text

Moore, Carlene, et al. “UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.Proc Natl Acad Sci U S A, vol. 110, no. 34, Aug. 2013, pp. E3225–34. Pubmed, doi:10.1073/pnas.1312933110. Full Text Open Access Copy

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