Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710


Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Bourque, Charles W., et al. “A TRP that makes us feel hyper.J Physiol, vol. 590, no. 8, Apr. 2012, pp. 1779–80. Pubmed, doi:10.1113/jphysiol.2012.229187. Full Text

Yang, Xiao-Ru, et al. “Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension.Am J Physiol Lung Cell Mol Physiol, vol. 302, no. 6, Mar. 2012, pp. L555–68. Pubmed, doi:10.1152/ajplung.00005.2011. Full Text

Ciura, Sorana, et al. “Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4.J Neurosci, vol. 31, no. 41, Oct. 2011, pp. 14669–76. Pubmed, doi:10.1523/JNEUROSCI.1420-11.2011. Full Text

Liedtke, Wolfgang B., et al. “Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.Proc Natl Acad Sci U S A, vol. 108, no. 30, July 2011, pp. 12509–14. Pubmed, doi:10.1073/pnas.1109199108. Full Text

Li, Jinju, et al. “TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.Environ Health Perspect, vol. 119, no. 6, June 2011, pp. 784–93. Pubmed, doi:10.1289/ehp.1002807. Full Text Open Access Copy

Ryskamp, Daniel A., et al. “The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.J Neurosci, vol. 31, no. 19, May 2011, pp. 7089–101. Pubmed, doi:10.1523/JNEUROSCI.0359-11.2011. Full Text

Pritschow, Bernd W., et al. “Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue.Pflugers Arch, vol. 461, no. 1, Jan. 2011, pp. 115–22. Pubmed, doi:10.1007/s00424-010-0883-4. Full Text

Shukla, Arun K., et al. “Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.J Biol Chem, vol. 285, no. 39, Sept. 2010, pp. 30115–25. Pubmed, doi:10.1074/jbc.M110.141549. Full Text

Ceppa, Eugene, et al. “Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.Am J Physiol Gastrointest Liver Physiol, vol. 299, no. 3, Sept. 2010, pp. G556–71. Pubmed, doi:10.1152/ajpgi.00433.2009. Full Text