Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710


Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Liedtke, Wolfgang. “Molecular mechanisms of TRPV4-mediated neural signaling.Ann N Y Acad Sci, vol. 1144, Nov. 2008, pp. 42–52. Pubmed, doi:10.1196/annals.1418.012. Full Text

Cenac, Nicolas, et al. “Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.Gastroenterology, vol. 135, no. 3, Sept. 2008, pp. 937-946.e2. Pubmed, doi:10.1053/j.gastro.2008.05.024. Full Text

Lorenzo, Ivan M., et al. “TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.Proc Natl Acad Sci U S A, vol. 105, no. 34, Aug. 2008, pp. 12611–16. Pubmed, doi:10.1073/pnas.0803970105. Full Text

Simon, S. A., and W. Liedtke. “How irritation: The role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.” Journal of Clinical Investigation, vol. 118, no. 7, July 2008, pp. 2383–86. Scopus, doi:10.1172/JC136111. Full Text

Simon, Sidney A., and Wolfgang Liedtke. “How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.J Clin Invest, vol. 118, no. 7, July 2008, pp. 2383–86. Pubmed, doi:10.1172/JCI36111. Full Text

Brierley, Stuart M., et al. “Selective role for TRPV4 ion channels in visceral sensory pathways.Gastroenterology, vol. 134, no. 7, June 2008, pp. 2059–69. Pubmed, doi:10.1053/j.gastro.2008.01.074. Full Text

Sipe, Walter E. B., et al. “Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.Am J Physiol Gastrointest Liver Physiol, vol. 294, no. 5, May 2008, pp. G1288–98. Pubmed, doi:10.1152/ajpgi.00002.2008. Full Text

Yin, Jun, et al. “Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4.Circ Res, vol. 102, no. 8, Apr. 2008, pp. 966–74. Pubmed, doi:10.1161/CIRCRESAHA.107.168724. Full Text

Jian, Ming-Yuan, et al. “High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.Am J Respir Cell Mol Biol, vol. 38, no. 4, Apr. 2008, pp. 386–92. Pubmed, doi:10.1165/rcmb.2007-0192OC. Full Text