Wolfgang Bernhard Liedtke
Professor of Neurology
Research Interests in the Liedtke-Lab:
- Pain/ nociception
- Sensory transduction and -transmission
- TRP ion channels
- Water and salt equilibrium regulated by the central nervous system
Deconstructing Cartilage Mechanotransduction by Piezo Channels awarded by National Institutes of Health (Principal Investigator). 2020 to 2025
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health (Collaborator). 2019 to 2024
Going on a migraine TRP: Defining mechanisms of action of botox on the trigeminal sensory system that provide an explanation for the anti-migraine pain effects of botox awarded by Allergan, Inc. (Principal Investigator). 2020 to 2023
LIlly I5Q-US-I011 awarded by Eli Lilly and Company (Principal Investigator). 2019 to 2021
COVID-19 Fast Grant awarded by George Mason University (Principal Investigator). 2020 to 2021
Novel pathways regulating calcium mediated contractility and inflammation in the pregnant uterus awarded by Stanford University (Principal Investigator). 2018 to 2021
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Not SciFi: How to Get Rid of Trigeminal Neuralgia awarded by The Facial Pain Research Foundation (Principal Investigator). 2018 to 2020
Simon, S. A., and R. Gutierrez. “TRP channels at the periphery of the taste and trigeminal systems.” Neurobiology of TRP Channels, 2017, pp. 113–24. Scopus, doi:10.4324/9781315152837. Full Text
Liedtke, W. “TRP channels and osmoregulation: TRPV4-mediated signaling.” TRP Channels in Health and Disease: Implications for Diagnosis and Therapy, 2011, pp. 153–70.
Rosenkranz, S. C., et al. “TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation.” Frontiers in Cell and Developmental Biology, vol. 8, Aug. 2020. Scopus, doi:10.3389/fcell.2020.00849. Full Text
Kuebler, Wolfgang M., et al. “Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.” American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 318, no. 6, June 2020, pp. L1239–43. Epmc, doi:10.1152/ajplung.00161.2020. Full Text
Swain, Sandip M., et al. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.” J Clin Invest, vol. 130, no. 5, May 2020, pp. 2527–41. Pubmed, doi:10.1172/JCI134111. Full Text
Ottolini, Matteo, et al. “Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.” Circulation, vol. 141, no. 16, Apr. 2020, pp. 1318–33. Pubmed, doi:10.1161/CIRCULATIONAHA.119.043385. Full Text
Xu, Biao, et al. “The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.” Br J Pharmacol, vol. 177, no. 1, Jan. 2020, pp. 93–109. Pubmed, doi:10.1111/bph.14848. Full Text
Gilchrist, Christopher L., et al. “TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.” Proc Natl Acad Sci U S A, vol. 116, no. 6, Feb. 2019, pp. 1992–97. Pubmed, doi:10.1073/pnas.1811095116. Full Text
Arredondo Zamarripa, David, et al. “Author Correction: Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference.” Sci Rep, vol. 8, no. 1, June 2018, p. 9652. Pubmed, doi:10.1038/s41598-018-27642-4. Full Text
Rodriguez, Erica, et al. “Publisher Correction: A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci, vol. 21, no. 6, June 2018, p. 896. Pubmed, doi:10.1038/s41593-018-0103-7. Full Text
Ciura, Sorana, et al. “Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission.” Cell Rep, vol. 23, no. 8, May 2018, pp. 2245–53. Pubmed, doi:10.1016/j.celrep.2018.04.090. Full Text
Mannaa, Marwan, et al. “Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion.” Sci Rep, vol. 8, no. 1, Mar. 2018, p. 4878. Pubmed, doi:10.1038/s41598-018-23165-0. Full Text
Seth, Ratanesh K., et al. “TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production.” Hepatology, vol. 64, WILEY, 2016, pp. 793A-794A.
Seth, Ratanesh Kumar, et al. “TRPV4 Modulates CYP2E1 Function in Nonalcoholic Steatohepatitis Progression.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.
Das, Suvarthi, et al. “TRPV4 deficiency enhances TLR4 recruitment to lipid rafts exhibiting exacerbated stellate cell activation and fibrosis in experimental nonalcoholic steatohepatitis.” Hepatology, vol. 62, WILEY-BLACKWELL, 2015, pp. 682A-682A.
Seth, Ratanesh K., et al. “TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress.” Hepatology, vol. 62, WILEY-BLACKWELL, 2015, pp. 1248A-1248A.
Bauer, W., et al. “Topical Anti-Inflammatory Therapy in the Treatment of Acute Migraine; Role of Trigeminal Nerve Peripheral Fibers.” Headache, vol. 55, WILEY-BLACKWELL, 2015, pp. 140–140.
Klein, R. C., et al. “Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1190–93. Scopus, doi:10.1109/NER.2013.6696152. Full Text
Sham, James S. K., et al. “UPREGULATION OF TRPV4 CHANNELS IN PULMONARY ARTERIES CONTRIBUTES TO CHRONIC HYPOXIA INDUCED MYOGENIC TONE AND PULMONARY HYPERTENSION.” Journal of Physiological Sciences, vol. 59, SPRINGER TOKYO, 2009, pp. 264–264.
Liedtke, W., et al. “Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 24, 2003, pp. 14531–36. Scopus, doi:10.1073/pnas.2235619100. Full Text
Kuebler, Wolfgang, et al. COVID-19: Urgent Reconsideration of Lung Edema as a Preventable Outcome: Inhibition of TRPV4 As a Promising and Feasible Approach. 23 Mar. 2020. Pubmed, doi:10.2139/ssrn.3558887. Full Text